Association of miRNAs with

Liver Disease

what is

Liver Disease?

Association of miRNAs with Liver Disease

Project1. Plasma levels of 2083 miRNAs were measured by RNA sequencing in 1999 participants from the population-based Rotterdam Study cohort. The Hounsfield Unit (HU) attenuation of liver was measured using non-enhanced computed tomography (CT) scan. Logistic and linear regression models adjusting for potential confounders were used to examine the association of circulatory miRNAs with liver enzymes and CT-based FLD. Moreover, the association of miRNAs with hepatic steatosis and liver fibrosis was assessed longitudinally in individuals who underwent abdominal ultrasound and transient elastography after a median follow-up of >6 years. We found 61 miRNAs significantly associated with serum GGT and ALP as well as 17 miRNAs associated with CT-based FLD, 14 of them were among the miRNAs associated with liver enzymes. Longitudinal analysis showed 4 (miR-193a-5p, miR-122-5p, miR-378d and miR-187-3p) of the 14 miRNAs significantly associated with hepatic steatosis and three (miR-193a-5p, miR-122-5p and miR-193b-3p) nominally associated with liver fibrosis.

Circulatory microRNAs as potential biomarkers for fatty liver disease: the Rotterdam study. Zhang X, …, Ghanbari M.
Aliment Pharmacol Ther. 2021 Feb;53(3):432-442. doi: 10.1111/apt.16177.

Project2. We describe briefly the potential clinical applications of microRNAs for the diagnosis of fatty liver disease.
Editorial: microRNAs for the diagnosis of fatty liver disease in the population-are we inching closer towards the target? Authors’ reply. Zhang X, Ghanbari M. Aliment Pharmacol Ther. 2021 Feb;53(4):559-560. doi: 10.1111/apt.16234.

Project3. We performed a systematic review of human epigenetic studies on FLD. In total 36 articles, based on 33 unique studies, consisting of 12,112 participants met the inclusion criteria. Among these, two recent epigenome-wide association studies conducted among large population-based cohorts have reported the association between cg06690548 (SLC7A11) and FLD. Moreover, several studies have demonstrated the association between miRNAs and FLD, in which miR-122, miR-34a and miR-192 were recognized as the most relevant miRNAs as biomarkers for FLD.

Deciphering the role of epigenetic modifications in fatty liver disease: A systematic review. Zhang X, …, Ghanbari M.
Eur J Clin Invest. 2021 May;51(5):e13479. doi: 10.1111/eci.13479.


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