miRnomics Atlas
Integration other omics with miRNAs
miRNAs dictate their role in biological processes by regulating the expression of target genes (mRNAs). Therefore, it is interesting to know whether miRNA-associated SNPs or miRNA-eQTLs are linked to the expression of coding genes, including their host and target genes. To explore this, we sought overlaps between miRNA-eQTLs and gene expression (eQTLs), protein-QTLs, and metabolite-QTLs. To this end, summary statistics for genetic variants that influence expression levels of mRNA transcripts (cis and trans-eQTLs) in whole blood from a previous large-scale study (N=31,684) were used to identify miRNA-eQTLs that affect the expression of other genes. Likewise, protein-QTLs (pQTLs) summary results were used to identify miRNA-eQTLs affecting protein levels in the blood. Summary statistics from two common metabolomics platforms, Metabolon and Nightingale, were also used to identify miRNA-eQTLs affecting metabolic pathways by investigating plasma levels of metabolites (see Ref).
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