Association of miRNAs with

Bone Disease

what is

Bone Disease?

Association of miRNAs with Bone Disease

We aimed to identify miRNAs that are involved in BMD using data from recent genome-wide association studies (GWAS) on femoral neck, lumbar spine and forearm BMD. Of 242 miRNA-variants available in the GWAS data, we found SNP in the precursor miR-196a-2 to be significantly associated with femoral neck-BMD and lumbar spine-BMD. Our sensitivity analyses using the Rotterdam study data showed a sex-specific association of miR-196a-2 SNP with BMD only in women. We highlighted a number of miR-196a-2 target genes, expressed in bone and associated with BMD, that may mediate the miRNA function in BMD.

Genetic Polymorphism of miR-196a-2 is Associated with Bone Mineral Density (BMD). Karabegović I, .., Ghanbari M. Int J Mol Sci. 2017 Nov 25;18(12):2529. doi: 10.3390/ijms18122529.


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